Physics of Living Systems (PoLS) research explores physical processes that living systems utilize to perform diverse functions in dynamic and diverse environments. It advances our understanding of the living world in a quantitative way, while also striving to provide insight from biological applications to expand the intellectual range of physics. PoLS research covers a broad spectrum of physics approaches in biology, ranging from the physical principles and mechanisms at the single-cell level such as molecular architecture and dynamics inside cells, energy metabolism, gene regulation, and intracellular and intercellular communication, to organismal biophysics, to collective behavior and evolution of complexity in life forms and living populations of organisms. Georgia Tech’s PoLS research has a special emphasis on interactions between living systems and their complex environments.