QBioS Seminar Series - Lijiang Long

The impact of Dobzhansky-Muller site on genome structure

Dobzhansky-Muller sites play very important roles in hybrid incompatibility and speciation over evolution. However, its effect on organismal fitness and population genome structure remains elusive. In this talk, I’ll talk about a detailed study of Dobzhansky-Muller site that is a toxin/antidote system. Using quantitative assays and forward evolution simulation, I’ll show how could this site spread through population and have changed genome structure of the whole population.